Cinnomer®


(Glatiramer Acetate)

Simplicity, Reliability, Safety


Description

Glatiramer acetate, the active ingredient of Cinnomer®, consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000–9,000 Daltons. Glatiramer acetate is identified by specific antibodies.

Chemically, glatiramer acetate is designated L-glutamic acid polymer with L-alanine, L-lysine and L-tyrosine, acetate (salt). Its structural formula is:

(Glu, Ala, Lys, Tyr)xxCH3COOH

(C5H9NO4●C3H7NO2●C6H14N2O2●C9H11NO3)xxC2H4O2

Cinnomer® is a clear, colorless to slightly yellow, sterile, nonpyrogenic solution for subcutaneous injection. Each 1 mL of Cinnomer® solution contains 40 mg of glatiramer acetate and the following inactive ingredient: 40 mg of mannitol. The pH of the solutions is approximately 5.5 to 7.0. The biological activity of glatiramer acetate is determined by its ability to block the induction of experimental autoimmune encephalomyelitis (EAE) in mice.

Indication and Usage

Cinnomer® is indicated for the treatment of patients with relapsing forms of multiple sclerosis.

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