(Pegylated Filgrastim)

Feel Neutrophil Stability

What is it?

What is PegaGen®?

PegaGen® is the brand name of Pegfilgrastim. PegaGen® is supplied in 6 mg/0.6 mL prefilled syringes and autoinjectors (Physioject™). This drug is available in pack containing 1 sterile pre-filled syringe or Physioject™ and a patient information leaflet.


What is PegaGen® used for?

PegaGen® is used to prevent neutropenia (a lack of certain white blood cells) that is caused by receiving chemotherapy.


When PegaGen® should not be used?

Do not take PegaGen® if you have had a serious allergic reaction to Pegfilgrastim or filgrastim or any component of the formulation.

Important information

What should you know about taking PegaGen®?

  • You should only receive a dose of PegaGen® on the day your healthcare provider tells you. You should not receive your dose of PegaGen® any sooner than 24 hours after you finish receiving your
  • You should not inject a fixed dose of 6 mg PegaGen® to children weighing less than 45 kg. Dosing is based on patient weight in this group. So you should not use Physioject™ for children weighing less than 45 kg.
  • Throw away expired drugs. Do not use if the solution is cloudy, leaking, changes color or has particles. Keep PegaGen® out of the reach of children.

What other drugs could affect PegaGen®?

Other drugs may affect PegaGen®, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

How to use PegaGen®?

Always use PegaGen® exactly as your doctor has told you.

The usual dose for Adolescents >45 kg is one 6 mg subcutaneous injection (injection under your skin) and it should be given 24-72 hours after your last dose of chemotherapy at the end of each chemotherapy cycle.

Dosing for children and Adolescents <45 kg is 100 μg/kg and is injected under your skin.

Is PegaGen® safe during pregnancy and breastfeeding?

Tell your doctor or pharmacist if you are pregnant or breast-feeding before using PegaGen®.

What happens if you miss a dose?

If you miss a dose of PegaGen®, inject drug as soon as possible. Unless you are close to injection of next dose. Talk to your doctor about the missing dose.

What happens if you overdose?

Seek emergency medical attention or call your doctor or pharmacist in cases of overdose.

Side Effects

What are some side effects of PegaGen®?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away.

The most common side effects of this drug are pain in the bones, arms, and legs. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects.


How to store PegaGen®?

  • Store PegaGen® between 2- 8 °C (in refrigerator) and do not freeze.
  • Avoid freezing; if frozen, thaw in the refrigerator before administration.
  • Discard PegaGen® if frozen more than once.
  • Store PegaGen® in its original package in the refrigerator, protected from light and Do not shake.
  • Discard PegaGen® stored at room temperature for more than 48 hours.
  • Keep PegaGen® in a safe place and out of the reach of children.