The monoclonal Anti-D reagents are human monoclonal antibodies of both IgM and IgG classes secreted by human cell lines. CinnaClone Anti-D IgM consists of one human IgM monoclonal antibody, and CinnaClone Anti-D Blend is composed of a mixture of human monoclonal antibodies, from both IgG and IgM classes.
The noted monoclonal Anti-D reagents were selected for their ability to agglutinate specifically human RBCs bearing Rh's antigen D on direct agglutination tests (slide, microplate and tube test). The monoclonal Blend Anti-D may be used in indirect antiglobulin test (Coombs' test) due to incomplete IgG components. The reagents do not demonstrate any cross reactivity and also do not induce any non-specific agglutination of D negative erythrocytes.