Anti-Human Globulin is antibody
produced by goat in response to deliberate immunization
with purified human immunoglobulins or complement (primarily
beta globulins). Anti-Human Globulin is used in the antiglobulins
test that is a sensitive technique used to detect human
immunoglobulins and/or complement components bound to
human erythrocytes. Anti-Human Globulin is used in a Direct
Antiglobulin Test (DAT) to detect antibodies and/or complement
bound to red cells in vivo. Direct Antiglobulin Test results
may support the diagnosis of Auto-Immune Hemolytic Anemia
(AIHA), Hemolytic Disease of the Newborn (HDM) and Delayed
Hemolytic Transfusion Reactions (DHTR). An Indirect Antiglobulin
Test (IAT) detect immunoglobulin and/or complement bound
to red cells in vitro and is the basis for a wide variety
of immunohematology tests, including: Du tests; crossmatch
tests; detection and identification of unexpected blood
group antibodies and red cell phenotyping.
