| Product |
Cloprostenol |
| Drug
category |
Prostaglandin |
| Description |
Cloprostenol is a synthetic
prostaglandin analogue of F2α for use in cattel, horses,
and pigs. |
| Storage |
Store in a dark and dry
place at 6-25°C |
| Pharmacological
mechanism |
Cloprostenol is a functional
analogue of prostaglandin F2α having a specific
luteolytic action. It causes functional and morphological
regression of the corpus luteum (luteolysis) in cattles
and horses followed by return to oestrus and normal ovulation. |
| Indications |
Cloprostenol is recommended
and specifically used in:
- Induction and synchronization of heat in heifers and
cows
- Synchronization of oestrus cycle in donor
- Recipient in the programs of embryo transfer in cattle
- Induction of farrowings in sows
- Treatment of functional disorders of ovaries
- Post-Partum and post service anoestrous
- Irregular and anovulatory cycles
- Persistent corpus luteum
- Luteal cysts
- Postpuerperal uterine disease
- Endometritis
- Pyometra
- Termination of normal or pathologic pregnancy at the
first half of gestation
- Follicular cysts on day 10th to 14th after administration
of LHRH or hCG |
| Contra-indications,
warnings, etc |
- Cloprostenol should
not be administered to pregnant animal unless the objective
is to
terminate the pregnancy
- Cloprostenol can be absorbed through the skin and therefor
care should be taken when
handling the product especially by women of child-bearing
age and by asthmatics
- Accidental spillage on the skin should be washed off
immediately with water
- Cloprostenol may cause broncho-spasm in man. Accidental
inhalation or injection may
cause a rapid acting broncho-dilation
- Cloprostenol may cause peritonitis in the cases that
they are in pyometral condition with a
stenosed cervix
- Cloprostenol in horses may cause hyperrythmia and colic
with hyper hidrosis |
| Withdrawal
time |
For meat and other organs
24hours |
| Note |
There is a refractory
period of four to five days after ovulation. |
